In vivo acetylcholine receptor dynamics at neuromuscular junctions

Research report (imported) 2009 - Max Planck Institute for Medical Research

Authors

Yampolsky, Pessah; Pacifici, Pier-Giorgio; Chevessier, Frédéric; Mersdorf, Ulrike; Barenhoff, Karina; Koenen, Michael; Witzemann, Veit

Departments

Gruppe Witzemann / Koenen - Molekulare Anatomie neuromuskulärer Synapsen (Prof. Dr. Veit Witzemann)
MPI für medizinische Forschung, Heidelberg

Summary

Synaptogenesis and synaptic plasticity require interactions between pre- and postsynaptic components. The neuromuscular synapse as model and genetically manipulated mice were used to study the dynamics of acetylcholine receptors. Direct in vivo analysis shows how newly synthesized receptors are integrated into the existing synapse and how receptor stability changes when muscle is inactivated by innervation.

For the full text, see the German version.