Broichhagen, Johannes
Johannes Broichhagen
Phone: 49 6221 486-620
Room: R. 208

Departmental Seminar (Chemical Biology) with David J. Hodson (Institute of Metabolism and Systems Research University of Birmingham)

Title: Shining light on beta cell heterogeneity and insulin release in the intact pancreatic islet

Friday March 23rd, 2018

Time: 3 pm

Place: Seminar Room C, 1st floor, Jahnstr. 29


Type 2 diabetes (T2D) currently affects ~10% of the UK adult  population and is one of the foremost health challenges currently facing society. This syndrome can be described as a failure of  the pancreatic beta cell mass to secrete sufficient insulin to  counteract elevated blood glucose levels. It is largely believed  that all beta cells are the same. However, recent studies have  shown that beta cells in fact comprise discrete subpopulations,  some of which may contribute to insulin secretion and T2D more  than others. This presentation will highlight the optical tools that  have allowed us to redefine how beta cells –and more generally  endocrine cells– function. The influence of subtle differences in  the beta cell “barcode” on insulin release in health and disease  will then be  examined. Finally, new techniques, which may  provide unprecedented insight into T2D and drug development,  will be discussed. 

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