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Seminars Biomolecular Mechanisms: Thermodynamics and Kinetics of Electron Transfer in Bifurcating Flavoproteins

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Thermodynamics and Kinetics of Electron Transfer in Bifurcating Flavoproteins

  • Date: Apr 16, 2018
  • Time: 12:30
  • Speaker: Prof. Dr. Anne-Frances Miller
  • University of Kentucky
  • Location: MPI for Medical Research
  • Room: Seminar Room C
  • Host: Prof. Dr. Ilme Schlichting

Abstract

Flavins have been known for over a hundred years, and yet we still have more to learn. The newly-recognized process of flavin-based electron bifurcation in a particularly significant example, as it captures excess free energy from exergonic electron transfers and provides low potential electrons to drive demanding reactions such as reduction of dinitrogen. This presentation will summarize thermodynamic as well as kinetic properties believed to underlie bifurcating activity, in the examples of the Fix system that supplies electrons to nitrogenase as well as the NfnI system that redistributes energy equivalents between the NADH and NADPH pools. We note that biology has chosen a cofactor whose native chemistry is poised between the functions displayed by the two flavins in the Fix system, enabling relatively modest interactions with the protein environment to tune the flavin's activity between these two.

 
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