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Seminars Chemical Biology: Imaging spatio-temporal signaling programs regulating cell fate decisions and cell morphogenesis.

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Imaging spatio-temporal signaling programs regulating cell fate decisions and cell morphogenesis

  • Date: Jun 22, 2018
  • Time: 12:00
  • Speaker: Prof. Dr. Olivier Pertz
  • Location: MPI for Medical Research
  • Room: Seminar Room C
  • Host: Prof. Dr. Kai Johnsson

Abstract

We study spatio-temporal dynamics of signaling regulating cell morphogenesis and cell fate decision at the single cell level. A combination of live cell imaging, microfabrication, computer vision, and mathematical modelling allows us to dissect novel properties of signaling networks, not accessible using classic biochemica/cell biological techniques. I will discuss how robust directional cell migration emerges using a self-organized cytoskeletal module that precisely positions signaling activities in single cells. I will also discuss how one can dissect signaling network architectures that produce dynamic signaling states regulating cell fate decisions such as proliferation or differentiation. This offers new insight to reprogram cell fate decisions at will.

 
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