Room: Seminar Room C

Enabling Innovation with the Max Planck Innovation GmbH

Enabling Innovation with the Max Planck Innovation GmbH

Workshop with IDEA Bio-Medical - Automated Microscopy

Workshop with IDEA Bio-Medical - Automated Microscopy

Leading Teams in Academia: Multiple Perspectives for Greater Awareness

Leading Teams in Academia: Multiple Perspectives for Greater Awareness
Workshop for staff members. [more]

CB Seminar with Martin Distel (Children's Cancer Research Institute)

CB Seminar with Martin Distel (Children's Cancer Research Institute)
Title of the talk: Modeling Cancer in Zebrafish – current strategies and novel tools [more]

Strategic Planning of Research Careers (Postdoc Workshop)

Strategic Planning of Research Careers (Postdoc Workshop)
Workshop for staff members. [more]

December PhD/Postdoc Seminar

December PhD/Postdoc Seminar

CB Seminar with Thomas Carell (LMU München)

CB Seminar with Thomas Carell (LMU München)
Title: DNA Bases beyond Watson and Crick T. Carell, Center for Integrative Protein Science at the Department of Chemistry, Ludwig Maximilians University, Munich, Butenandtstr. 5-13, 81377; e-mail: thomas.carell@lmu.de; www.carellgroup.de Keywords: Epigenetics, oxidized pyrimidine bases, mass spectrometry, proteomics. Abstract: Epigenetic information is stored in the form of modified bases in the genome. The positions and the kind of the base modifications determines the identity of the corresponding cell. Setting and erasing of epigenetic imprints controls the complete development process starting from an omnipotent stem cells and ending with an adult specialized cell. I am going to discuss results related to the function and distribution of the new epigenetic bases 5-hydroxymethylcytosine (hmC), 5-formylcytosine (fC), 5-carboxycytosine (caC) and 5-hydroxymethyluracil (Scheme 1).[1] These nucleobases seem to control epigenetic programming of cells and establish genetic programmability. Synthetic routes to these new bases will be discussed that enable the preparation of oligonucleotides. The second part of the lecture will cover mass spectroscopic approaches to decipher the biological functions of the new bases.[2] In particular, results from quantitative mass spectrometry, new covalent-capture proteomics mass spectrometry and isotope tracing techniques will be reported.[3] Finally I am dicussing potential präbiotic origins of modified bases[4]. [more]

CBP Seminar with C. Nadir Kaplan (Harvard University)

CBP Seminar with C. Nadir Kaplan (Harvard University)
Title: Theoretical design of hard and soft biomimetic materialsTheoretical design of hard and soft biomimetic materialsC. Nadir KaplanPaulson School of Engineering and Applied Sciences, Harvard UniversityRealizing next-generation materials with intricate shapes or complex signal processing abilities to perform adaptive functions greatly benefits inspiration from biological systems. In the first part of this talk, I will present a geometrical theory that explains the growth and form of carbonate-silica precipitates, which exemplify biomineralization-inspired formation of inorganic brittle microarchitectures. The theory predicts new assembly pathways of arbitrarily complex morphologies and thereby guides the synthesis of light-guiding optical structures. The second part will concern a soft matter analog of information storage and differentiation in living organisms, which constantly process dynamic environmental signals. Specifically, I will introduce a continuum framework of a hydrogel system that utilizes unique cascades of mechanical responses, transport and complexation of chemical stimuli to expand the sensing repertoire beyond standard hydrogels that rapidly equilibrate to their surroundings. Altogether, the confluence of theory and experiment enables the design of optimized hard or soft biomimetic materials for applications ranging from bottom-up manufacturing to soft robotics to data encoding. [more]

CBP/ON Seminar with Fulvio Chiacchiera (IEO)

CBP/ON Seminar with Fulvio Chiacchiera (IEO)
Title: Polycomb activities preserving stem cell identity and tissue homeostasis [more]

February PhD/Postdoc Seminar with Jan Ellenberg (EMBL)

February PhD/Postdoc Seminar with Jan Ellenberg (EMBL)

March PhD/Postdoc Seminar

March PhD/Postdoc Seminar

April PhD/Postdoc Seminar

April PhD/Postdoc Seminar

May PhD/Postdoc Seminar

May PhD/Postdoc Seminar

May PhD and Postdoc seminar

May PhD and Postdoc seminar

July PhD and Postdoc Seminar

July PhD and Postdoc Seminar

September PhD/Postdoc Seminar

September PhD/Postdoc Seminar

Proposal Writing (Workshop)

Proposal Writing (Workshop)

Time and Stress Management for Scientists (Workshop)

Time and Stress Management for Scientists (Workshop)

October PhD/Postdoc Seminar

October PhD/Postdoc Seminar

BMM Departmental Seminar with Visiting Prof. Jeffrey L. Blanchard on ' Giant Viruses, Chlamydia, Vampire Bacteria and the Unexpected Diversity in Soil Microbial Life at Harvard Forest'

BMM Departmental Seminar with Visiting Prof. Jeffrey L. Blanchard on ' Giant Viruses, Chlamydia, Vampire Bacteria and the Unexpected Diversity in Soil Microbial Life at Harvard Forest'
The Harvard Forest Long Term Ecological Research site in Petersham, MA is home to long-term experimental soil warming sites heated continuously to 5° C above ambient temperature since 1991 (Prospect Hill), 2003 (Barre Woods) and 2006 (SWaN). The net short-term effect of warming on forest soil communities is increased microbial activity, which translates to increased CO2 flux to the atmosphere and lower soil organic carbon levels. Several challenges remain to directly link soil communities to changes in soil CO2 efflux. Consequently, it is essential that we develop alternative methods for analyzing community composition and function of active community members. Cells were labeled using SYBR green and separated by fluorescence activated cell sorting. To improve cost efficiency and throughput over single cells genomic methods, 360 subpools of 100 cells each were sequenced. This approach, termed mini-metagenomics, resulted in ~2,000 distinct genome bins. Phylogenomic analysis revealed a surprising diversity of microbial life. Sixteen new lineages of giant viruses were discovered for the first time in a forest soil ecosystem. Intracellular and host-dependent bacteria (Chlamydiae, Legionellales, Bacteriodetes, Rickettsiales and TM6/Dependentiae) were enriched in the data set relative to abundances in our traditional metagenomics data set of DNA extracted directly from the soil and further over-represented among high quality genome bins. Among the bins were several relatives of unusual parasitic vampire bacteria. This collection of mini-MAGs exposes a reservoir of genetic diversity in difficult to cultivate organisms, some of which are related to human pathogens. [more]

ON Departmental Seminar with Frank Biedermann (KIT) on 'Supramolecular Sensing Ensembles: More Information through Communication'

ON Departmental Seminar with Frank Biedermann (KIT) on 'Supramolecular Sensing Ensembles: More Information through Communication'
The detection of spectroscopically silent analytes in water is often accomplished by utilization of reactive probes that form chromophoric analyte-dye conjugates. Unfortunately, similar but distinctly different analytes usually do not provide unique spectroscopic features, such that chromatographic separation steps have to be employed, causing significant additional costs and hinder applications. Supramolecular indicator-dye displacement assays can overcome certain limitations of reactive-probes, e.g., they allow for an in situ detection of even non-functionalizable analytes and are of great utility for reaction monitoring. However, their analyte differentiation capabilities are again restricted. Here, we present new strategies involving supramolecular sensing ensembles that allow for improved analyte differentiation through spectroscopic fingerprints. We show that this strategy is applicable to both non-covalent analyte-receptor binding schemes and to reactive-probe assays. As opposed to contemporary sensing strategies, our approach capitalizes on induced spectroscopic changes that are resulting from, (A) the direct “communication” of the analyte with a suitable reporter dye in a confined receptor cavity, or (B) from the analyte-induced structural changes of supramolecular dye-aggregates, leading to an altered dye-dye “communication”. [more]

November PhD/Postdoc Seminar with Petra Schwille

November PhD/Postdoc Seminar with Petra Schwille

CB Departmental Seminar with Bruno Correia (EPFL) on 'Computational Design of Functional Proteins for Biomedicine and Synthetic Biology'

CB Departmental Seminar with Bruno Correia (EPFL) on 'Computational Design of Functional Proteins for Biomedicine and Synthetic Biology'

PhD/Postdoc Seminar with Raphaël Rodriguez

PhD/Postdoc Seminar with Raphaël Rodriguez
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