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BEGIN:VEVENT
DTSTAMP:20240328T144538Z
UID:https://www.mr.mpg.de/events/16109/2169
DTSTART:20181212T100000Z
DTEND:20181212T110000Z
CLASS:PUBLIC
CREATED:20181115T084442Z
DESCRIPTION: Title: DNA Bases beyond Watson and Crick T. Carell\, Center
for Integrative Protein Science at the Department of Chemistry\, L
udwig Maximilians University\, Munich\, Butenandtstr. 5-13\, 81377\; e
-mail: thomas.carell@lmu.de\; www.carellgroup.de Keywords: Epigenetics\, o
xidized pyrimidine bases\, mass spectrometry\, proteomics. Abstra
ct: Epigenetic information is stored in the form of modified bases in the
genome. The positions and the kind of the base modifications determines th
e identity of the corresponding cell. Setting and erasing of epigenetic im
prints controls the complete development process starting from an omnipote
nt stem cells and ending with an adult specialized cell. I am going to dis
cuss results related to the function and distribution of the new epigeneti
c bases 5-hydroxymethylcytosine (hmC)\, 5-formylcytosine (fC)\, 5-carboxyc
ytosine (caC) and 5-hydroxymethyluracil (Scheme 1).[1] These nu
cleobases seem to control epigenetic programming of cells and establish ge
netic programmability. Synthetic routes to these new bases will be discuss
ed that enable the preparation of oligonucleotides. The second part of the
lecture will cover mass spectroscopic approaches to decipher the biologic
al functions of the new bases.[2] In particular\, results from
quantitative mass spectrometry\, new covalent-capture proteomics mass spec
trometry and isotope tracing techniques will be reported.[3] Fi
nally I am dicussing potential präbiotic origins of modified bases[4
].
LAST-MODIFIED:20181203T092952Z
LOCATION:MPI for Medical Research\, Room: Seminar Room C
ORGANIZER:Prof. Dr. Kai Johnsson
SUMMARY:CB Seminar with Thomas Carell (LMU München): CB Seminar with Thoma
s Carell (LMU München)
URL:https://www.mr.mpg.de/events/16109/2169
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