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Journal Article (30)

  1. 1.
    Brandstaedter, C.; Fritz-Wolf, K.; Weder, S.; Fischer, M.; Hecker, B.; Rahlfs, S.; Becker, K.: Kinetic characterization of wild-type and mutant human thioredoxin glutathione reductase defines its reaction and regulatory mechanisms. The FEBS Journal (2017)
  2. 2.
    Bathke, J.; Fritz-Wolf, K.; Brandstädter, C.; Burkhardt, A.; Jortzik, E.; Rahlfs, S.; Becker, K.: Structural and functional characterization of Plasmodium falciparum nicotinic acid mononucleotide adenylyltransferase. Journal of Molecular Biology (London) 428 (24, Part B), pp. 4946 - 4961 (2016)
  3. 3.
    Pretzel, J.; Gehr, M.; Eisenkolb, M.; Wang, L.; Fritz-Wolf, K.; Rahlfs, S.; Becker, K.; Jortzik, E.: Characterization and redox regulation of Plasmodium falciparum methionine adenosyltransferase. The Journal of Biochemistry 160 (6), pp. 355 - 367 (2016)
  4. 4.
    Wang, L.; Delahunty, C.; Fritz-Wolf, K.; Rahlfs, S.; Prieto, J. H.; Yates, J. R.; Becker, K.: Characterization of the 26S proteasome network in Plasmodium falciparum. Scientific Reports (2015)
  5. 5.
    Mailu, B. M.; Li, L.; Arthur, J.; Nelson, T. M.; Ramasamy, G.; Fritz-Wolf, K.; Becker, K.; Gardner, M. J.: Plasmodium apicoplast Gln-tRNAGln biosynthesis utilizes a unique GatAB amidotransferase essential for erythrocytic stage parasites. The Journal of Biological Chemistry 290 (49), pp. 29629 - 29641 (2015)
  6. 6.
    Fritz-Wolf, K.; Jortzik, E.; Stumpf, M.; Preuss, J.; Iozef, R.; Rahlfs, S.; Becker, K.: Crystal structure of the Plasmodium falciparum thioredoxin reductase-thioredoxin complex. Journal of Molecular Biology (London) 425 (18), pp. 3446 - 3460 (2013)
  7. 7.
    Saul, V. V.; de la Vega, L.; Milanovic, M.; Krüger, M.; Braun, T.; Fritz-Wolf, K.; Becker, K.; Schmitz, M. L.: HIPK2 kinase activity depends on cis-autophosphorylation of its activation loop. Journal of molecular cell biology 5 (1), pp. 27 - 38 (2013)
  8. 8.
    Zocher, K.; Fritz-Wolf, K.; Kehr, S.; Fischer, M.; Rahlfs, S.; Becker, K.: Biochemical and structural characterization of Plasmodium falciparum glutamate dehydrogenase 2. Molecular and Biochemical Parasitology 183 (1), pp. 52 - 62 (2012)
  9. 9.
    Zocher, K.; Fritz-Wolf, K.; Kehr, S.; Fischer, M.; Rahlfs, S.; Becker, K.: Biochemical and structural characterization of Plasmodium falciparum glutamate dehydrogenase 2. Molecular and Biochemical Parasitology 183 (1), pp. 52 - 62 (2012)
  10. 10.
    Fritz-Wolf, K.; Kehr, S.; Stumpf, M.; Rahlfs, S.; Becker, K.: Crystal structure of the human thioredoxin reductase-thioredoxin complex. Nature Communications 2, 383, pp. 1 - 8 (2011)
  11. 11.
    Kasozi, D. M.; Gromer, S.; Adler, H.; Zocher, K.; Rahlfs, S.; Wittlin, S.; Fritz-Wolf, K.; Schirmer, R. H.; Becker, K.: The bacterial redox signaller pyocyanin as an antiplasmodial agent: comparisons with its thioanalog methylene blue. Redox Report 16 (4), pp. 154 - 165 (2011)
  12. 12.
    Sibbing, D.; Pfeufer, A.; Perisic, T.; Mannes, A. M.; Fritz-Wolf, K.; Unwin, S.; Sinner, M. F.; Gieger, C.; Gloeckner, C. J.; Wichmann, H. E. et al.; Kremmer, E.; Schäfer, Z.; Walch, A.; Hinterseer, M.; Näbauer, M.; Kääb, S.; Kastrati, A.; Schömig, A.; Meitinger, T.; Bornkamm, G. W.; Conrad, M.; von Beckerath, N.: Mutations in the mitochondrial thioredoxin reductase gene TXNRD2 cause dilated cardiomyopathy. European Heart Journal 32 (9), pp. 1121 - 1133 (2011)
  13. 13.
    Jortzik, E.; Fritz-Wolf, K.; Sturm, N.; Hipp, M.; Rahlfs, S.; Becker, K.: Redox regulation of Plasmodium falciparum ornithine δ-aminotransferase. Journal of Molecular Biology (London) 402 (2), pp. 445 - 459 (2010)
  14. 14.
    Sturm, N.; Hu, Y.; Zimmermann, H.; Fritz-Wolf, K.; Wittlin, S.; Rahlfs, S.; Becker, K.: Compounds structurally related to ellagic acid show improved intiplasmodial activity. Antimicrobial Agents and Chemotherapy 53 (2), pp. 622 - 630 (2009)
  15. 15.
    Fritz-Wolf, K.; Urig, S.; Becker, K.: The structure of human thioredoxin reductase 1 provides insights into C-terminal rearrangements during catalysis. Journal of Molecular Biology (London) 370 (1), pp. 116 - 127 (2007)
  16. 16.
    Bauer, H.; Fritz-Wolf, K.; Winzer, A.; Kühner, S.; Little, S.; Yardley, V.; Vezin, H.; Palfey, B.; Schirmer, R. H.; Davioud−Charvet, E.: A fluoro analogue of the menadione derivative 6-[2'-(3'-methyl)-1',4'-naphthoquinolyl]hexanoic acid is a suicide substrate of glutathione reductase. Crystal structure of the alkylated human enzyme. Journal of the American Chemical Society 128 (33), pp. 10784 - 10794 (2006)
  17. 17.
    Urig, S.; Fritz-Wolf, K.; Réau, R.; Herold-Mende, C.; Tóth, K.; Davioud-Charvet, E.; Becker, K.: Gold(I)-Phosphinkomplexe für die irreversible Hemmung von humanen Disulfid-Reduktasen. Angewandte Chemie 118 (12), pp. 1915 - 1920 (2006)
  18. 18.
    Urig, S.; Fritz-Wolf, K.; Réau, R.; Herold-Mende, C.; Tóth, K.; Davioud-Charvet, E.; Becker, K.: Undressing of phosphine gold(I) complexes as irreversible inhibitors of human disulfide reductases. Angew. Chem. Internat. Ed. 45 (12), pp. 1881 - 1886 (2006)
  19. 19.
    Hiller, N.; Fritz-Wolf, K.; Deponte, M.; Wende, W.; Zimmermann, H.; Becker, K.: Plasmodium falciparum glutathione S-transferase — structural and mechanistic studies on ligand binding and enzyme inhibition. Protein Science 15 (2), pp. 281 - 289 (2006)
  20. 20.
    Urig, S.; Lieske, J.; Fritz-Wolf, K.; Irmler, A.; Becker, K.: Truncated mutants of human thioredoxin reductase 1 do not exhibit glutathione reductase activity. FEBS Letters 580 (15), pp. 3595 - 3600 (2005)
 
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