Department of Biomolecular Mechanisms
For that, one needs to know a great deal about mechanism, intermediates, structural dynamics and molecular interactions. We gather this information using a wide range of biochemical and biophysical techniques, including molecular biology, transient kinetics and crystallography, mass spectrometry, and computation, to understand the "jigglings and wigglings of atoms" in model systems. We study mRNA processing, chaperone-assisted and unassisted protein folding, and reactions that make use of flavin or heme cofactors. In addition, we are exploring applications of Free-electron lasers for structural biology.