Quantitative Analysis of Biological and Biomedical Interface Phenomena
Analytical techniques developed in Physical Chemistry, Surface Physics and Interface Chemistry are used to quantitatively analyze biological and biomedical questions and to develop predictive models. Recent and ongoing research includes synchrotron based x-ray micro-spectroscopy to study the structure of melanosomes with respect to the development of glaucoma, microfluidic experiments to determine and model the kinetic parameters of cell attachment and detachment, super-hydrophobic and super-hydrophilic surfaces, various kinds of µ-spectroscopy to study the settlement process of marine organism in vivo, and in line holography to study the movement and settlement of marine bacteria on various surfaces in vivo in the search for bio-fouling resistant surface coatings. Ab initio quantum mechanical calculations and Grand Canonical Monte Carlo simulations were carried out to understand the role of hydration forces in and between membranes. I remain interested in Surface Chemistry and Interface Physics, biocompatible surface coatings, adhesion science, self-assembly of organic mono- and multilayers, x-ray absorption and x-ray emission spectroscopy, x- ray microscopy, in-line holography, and biochemical sensors.