Publikationen

Weyand, M.; Schlichting, I.: Structural basis for the impaired channeling and allosteric inter-subunit communication in the βA169L/βC170W mutant of tryptophan synthase. The Journal of Biological Chemistry 275 (52), S. 41058 - 41063 (2000)

Schlichting, I.; Chu, K.: Trapping intermediates in the crystal: ligand binding to myoglobin. Current Opinion in Structural Biology 10 (6), S. 744 - 752 (2000)

Ostermann, N.; Lavie, A.; Padiyar, S.; Brundiers, R.; Veit, T.; Reinstein, J.; Goody, R. S.; Konrad, M.; Schlichting, I.: Potentiating AZT activation: Structures of wild-type and mutant human thymidylate kinase suggest reasons for the mutants' improved kinetics with the HIV prodrug metabolite AZTMP. Journal of Molecular Biology (London) 304 (1), S. 43 - 53 (2000)

Ostermann, N.; Lavie, A.; Padiyar, S.; Brundiers, R.; Veit, T.; Reinstein, J.; Goody, R. S.; Konrad, M.; Schlichting, I.: Potentiating AZT activation: structures of wild-type and mutant human thymidylate kinase suggest reasons for the mutants' improved kinetics with the HIV prodrug metabolite AZTMP. Journal of Molecular Biology (London) 304 (1), S. 43 - 53 (2000)

Schlichting, I.: Crystallographic structure determination of unstable species. Accounts of Chemical Research 33 (8), S. 532 - 538 (2000)

Ostermann, N.; Schlichting, I.; Brundiers, R.; Konrad, M.; Reinstein, J.; Veit, T.; Goody, R. S.; Lavie, A.: Insights into the phosphoryltransfer mechanism of human thymidylate kinase gained from crystal structures of enzyme complexes along the reaction coordinate. Structure 8 (6), S. 629 - 642 (2000)

Schlichting, I.; Berendzen, J.; Chu, K.; Stock, A. M.; Maves, S. A.; Benson, D. E.; Sweet, R. M.; Ringe, D.; Petsko, G. A.; Sligar, S. G.: The catalytic pathway of cytochrome P450cam at atomic resolution. Science 287, S. 1615 - 1622 (2000)

Brunori, M.; Vallone, B.; Cutruzzola, F.; Travaglini−Allocatelli, C.; Berendzen, J.; Chu, K.; Sweet, R. M.; Schlichting, I.: The role of cavities in protein dynamics: Crystal structure of a photolytic intermediate of a mutant myoglobin. Proceedings of the National Academy of Sciences of the United States of America 97 (5), S. 2058 - 2063 (2000)

Chu, K.; Vojtchovsky, J.; McMahon, B. H.; Sweet, R. M.; Berendzen, J.; Schlichting, I.: Structure of a ligand-binding intermediate in wild-type carbonmonoxy myoglobin. Nature 403, S. 921 - 923 (2000)

Schlichting, I.; Berendzen , J.; Chu , K.; Stock , A.M.; Maves , S.A.; Benson , D.E.; Sweet , R.M.; Ringe , D.; Petsko , G.A.; Sligar , S.G.: Putative oxo complex of P450cam from pseudomonas putida. (2000), 22 S.